Mefenamic acid
Mefenamic Acid, Ponstel (mefenamic acid) is a small molecule pharmaceutical. Mefenamic acid was first approved as Ponstel on 1982-01-01. It is used to treat dysmenorrhea, fever, menorrhagia, and premenstrual syndrome in the USA. The pharmaceutical is active against prostaglandin G/H synthase 2 and prostaglandin G/H synthase 1. In addition, it is known to target transient receptor potential cation channel subfamily M member 3 and potassium voltage-gated channel subfamily KQT member 1.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| urogenital diseases | D000091642 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Mefenamic acid, Ponstel (discontinued: Mefenamic acid)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Mefenamic acid
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PONSTEL | Avion Pharmaceuticals | N-015034 RX | 1982-01-01 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| mefenamic acid | ANDA | 2025-06-24 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| menorrhagia | EFO_0003945 | D008595 | N92.0 |
| fever | — | D005334 | R50.9 |
| dysmenorrhea | — | D004412 | N94.6 |
| premenstrual syndrome | — | D011293 | N94.3 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
18 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dysmenorrhea | D004412 | — | N94.6 | — | 2 | 1 | 1 | 1 | 4 |
| Uterine hemorrhage | D014592 | — | — | — | — | — | 1 | 1 | 2 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pain | D010146 | EFO_0003843 | R52 | — | 2 | 1 | — | 1 | 3 |
| Menorrhagia | D008595 | EFO_0003945 | N92.0 | — | — | 1 | — | 1 | 2 |
| Endometriosis | D004715 | EFO_0001065 | N80 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postoperative pain | D010149 | — | G89.18 | — | 1 | — | — | — | 1 |
| Pulpitis | D011671 | EFO_1001139 | K04.0 | — | 1 | — | — | — | 1 |
| Progressive supranuclear palsy | D013494 | EFO_0002512 | G23.1 | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Drug interactions | D004347 | — | — | 2 | — | — | — | — | 2 |
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | 1 | — | — | — | — | 1 |
| Metabolic side effects of drugs and substances | D065606 | — | — | 1 | — | — | — | — | 1 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Amenorrhea | D000568 | — | N91.2 | — | — | — | — | 1 | 1 |
| Infertility | D007246 | EFO_0000545 | — | — | — | — | — | 1 | 1 |
| Impacted tooth | D014095 | — | K01.1 | — | — | — | — | 1 | 1 |
| Tooth diseases | D014076 | — | — | — | — | — | — | 1 | 1 |
| Metrorrhagia | D008796 | — | N92.1 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Mefenamic acid |
| INN | mefenamic acid |
| Description | Mefenamic acid is an aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3-dimethylphenyl group. Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to be minor. It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid arthritis. It has a role as an analgesic, an antirheumatic drug, a non-steroidal anti-inflammatory drug, an antipyretic, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, an environmental contaminant and a xenobiotic. It is an aminobenzoic acid and a secondary amino compound. |
| Classification | Small molecule |
| Drug class | anti-inflammatory agents (anthranilic acid derivatives) and their salts or esters |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1cccc(Nc2ccccc2C(=O)O)c1C |
Identifiers
| PDB | — |
| CAS-ID | 61-68-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL686 |
| ChEBI ID | 6717 |
| PubChem CID | 4044 |
| DrugBank | DB00784 |
| UNII ID | 367589PJ2C (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
AKR1C3
AKR1C3
Organism
Homo sapiens
Gene name
AKR1C3
Gene synonyms
DDH1, HSD17B5, KIAA0119, PGFS
NCBI Gene ID
Protein name
aldo-keto reductase family 1 member C3
Protein synonyms
17-beta-HSD 5, 17-beta-hydroxysteroid dehydrogenase type 5, 3-alpha hydroxysteroid dehydrogenase, type II, 3-alpha-HSD type 2, 3-alpha-HSD type II, brain, 3-alpha-hydroxysteroid dehydrogenase type 2, Chlordecone reductase homolog HAKRb, DD-3, DD3, Dihydrodiol dehydrogenase 3, Dihydrodiol dehydrogenase type I, dihydrodiol dehydrogenase X, HA1753, indanol dehydrogenase, PGFS, Prostaglandin F synthase, Testosterone 17-beta-dehydrogenase 5, trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, type IIb 3-alpha hydroxysteroid dehydrogenase
Uniprot ID
Mouse ortholog
—
—
Variants
No data
Financial
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Estimated US medical usage
Mefenamic acid
Total medical expenditures per year (USD, in millions)
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Number of purchases
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 4,345 documents
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Safety
Black-box Warning
Black-box warning for: Mefenamic acid
Adverse Events
Top Adverse Reactions
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1,281 adverse events reported
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